Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool.

@article{Bukh1998ExperimentalIO,
  title={Experimental infection of chimpanzees with hepatitis C virus of genotype 5a: genetic analysis of the virus and generation of a standardized challenge pool.},
  author={Jens Bukh and Charles Apgar and Ronald E Engle and Sugantha Govindarajan and P A Hegerich and Raymond Tellier and Doris C Wong and Randy Elkins and Michael Charles Kew},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={178 4},
  pages={1193-7}
}
Six major genotypes (genotypes 1-6) of hepatitis C virus (HCV) have been identified. These genetic variants are being transmitted to chimpanzees, the only recognized animal model for the study of HCV. Genotype 5a (strain SA13), a variant found primarily in South Africa, has been transmitted to chimpanzees for the first time. Experimental infection of 2 chimpanzees was characterized by early appearance of viremia and peak virus titers of 10(5)-10(6) genome equivalents/mL. The HCV infection was… CONTINUE READING

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