Experimental infection of bats with Geomyces destructans causes white-nose syndrome

  title={Experimental infection of bats with Geomyces destructans causes white-nose syndrome},
  author={Jeffrey M. Lorch and Carol Uphoff Meteyer and Melissa J. Behr and Justin G. Boyles and Paul M. Cryan and Alan C. Hicks and Anne Ballmann and Jeremy T. H. Coleman and David N. Redell and D. M. Reeder and David S. Blehert},
White-nose syndrome (WNS) has caused recent catastrophic declines among multiple species of bats in eastern North America. The disease’s name derives from a visually apparent white growth of the newly discovered fungus Geomyces destructans on the skin (including the muzzle) of hibernating bats. Colonization of skin by this fungus is associated with characteristic cutaneous lesions that are the only consistent pathological finding related to WNS. However, the role of G. destructans in WNS… 
Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome
It is demonstrated that altered torpor-arousal cycles underlie mortality from white-nose syndrome and provide direct evidence that Gd is a novel pathogen to North America from Europe.
White-Nose Syndrome in Hibernating Bats
Molecular investigations revealed a single clonal genotype for North America, while European isolates diversified, providing strong support for the hypothesis of an introduction of Pd from Europe into a naive bat population in North America.
White-Nose Syndrome in Bats
A synthesis of the current state of knowledge on white-nose syndrome, including disease mechanisms, disease ecology, global distribution and conservation and management efforts is presented.
Skin Lesions in European Hibernating Bats Associated with Geomyces destructans, the Etiologic Agent of White-Nose Syndrome
White-nose syndrome (WNS) has claimed the lives of millions of hibernating insectivorous bats in North America. Its etiologic agent, the psychrophilic fungus Geomyces destructans, causes skin lesions
Potential Spread of White-Nose Syndrome of Bats to the Northwest: Epidemiological Considerations
Current epidemiological knowledge about white-nose syndrome is summarized, in an ecological context relevant to efforts to understand the epidemic and predict its potential to spread to western bat populations.
Experimental Infection of Tadarida brasiliensis with Pseudogymnoascus destructans, the Fungus That Causes White-Nose Syndrome
Tadarida brasiliensis is not likely a suitable experimental model for WNS research, but the recovery of viable WNS-causing fungus from experimentally infected bats indicates a potential for this species to contribute to the spread of the pathogen where it coexists with other species of bats affected by WNS.
Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America with No Sign of Recombination
Since its discovery in 2006, the emerging infectious disease known as white-nose syndrome has killed millions of bats in North America, making it one of the most devastating wildlife epidemics in
Out of the dark abyss: white-nose syndrome in bats
  • G. Wibbelt
  • Environmental Science
    Veterinary Record
  • 2015
White-nose syndrome in bats is recognised as causing one of the worst declines in wildlife mammal populations over the last century, and it was found that it was always associated with a distinct external fungal infection.
White-Nose Syndrome Fungus: A Generalist Pathogen of Hibernating Bats
Investigation of Pseudogymnoascus destructans infection in relation to chiropteran ecology, behaviour and phylogenetics suggests that the pathogen may be a generalist and that all bats hibernating within the distribution range of P. destructans may be at risk of infection.
Ecology and impacts of white-nose syndrome on bats
Collectively, this research highlights how early pathogen detection and quantification of host impacts has accelerated the understanding of this newly emerging infectious disease.


Pan-European Distribution of White-Nose Syndrome Fungus (Geomyces destructans) Not Associated with Mass Mortality
The characterisation of the temporal variation in G. destructans growth on bats provides reference data for studying the spatio-temporal dynamic of the fungus, and the presence of G. destructionans spores on cave walls suggests that hibernacula could act as passive vectors and/or reservoirs for G.destructans and therefore, might play an important role in the transmission process.
Investigating and managing the rapid emergence of white-nose syndrome, a novel, fatal, infectious disease of hibernating bats.
Adaptive-management options for white-nose syndrome include an ongoing program of prospective surveillance of bats and hibernacula for WNS, treatment of individual bats, increasing population resistance to WNS (through vaccines, immunomodulators, or other methods, improving probability of survival from starvation and dehydration associated with WNS), modifying hibernACula environments to eliminate G. destructans.
Wing pathology of white-nose syndrome in bats suggests life-threatening disruption of physiology
The unique physiological importance of wings to hibernating bats in relation to the damage caused by G. destructans is reviewed and it is proposed that mortality is caused by catastrophic disruption of wing-dependent physiological functions.
Histopathologic Criteria to Confirm White-nose Syndrome in Bats
  • C. Meteyer, E. Buckles, M. Behr
  • Biology
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2009
White-nose syndrome (WNS) is a cutaneous fungal disease of hibernating bats associated with a novel Geomyces sp. fungus. Currently, confirmation of WNS requires histopathologic examination. Invasion
Bat White-Nose Syndrome: An Emerging Fungal Pathogen?
Direct microscopy and culture analyses demonstrated that the skin of WNS-affected bats is colonized by a psychro-philic fungus that is phylogenetically related to Geomyces spp.
Increasing Incidence of Geomyces destructans Fungus in Bats from the Czech Republic and Slovakia
White-nose syndrome was found to be widespread in the Czech Republic and Slovakia, with an epizootic incidence in bats during the most recent years, and the recorded population decline in the last two years of the most affected species, M. myotis, is within the population trend prediction interval.
An Emerging Disease Causes Regional Population Collapse of a Common North American Bat Species
It seems that although rabies viruses have the potential for rapid evolution, this property alone is not enough to overcome genetic barriers, which inhibit the onward transmission of rabies virus into a new species.
White-Nose Syndrome Fungus (Geomyces destructans) in Bat, France
White-nose syndrome is caused by the fungus Geomyces destructans and is responsible for the deaths of >1,000,000 bats since 2006. This disease and fungus had been restricted to the northeastern
Geomyces destructans sp. nov. associated with bat white-nose syndrome.
Based on rRNA gene sequence (ITS and SSU) characters the fungus is placed in the genus Geomyces, yet its distinctive asymmetrically curved conidia are unlike those of any described Geomyce species.
Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection?