Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus).

  title={Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus).},
  author={Jason Botten and Katy Mirowsky and Donna Frances Kusewitt and Mausumi Bharadwaj and Joyce S. R. Yee and Rosalba Ricci and Rodney M Feddersen and Brian Hjelle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 19},
The relationship between hantaviruses and their reservoir hosts is not well understood. We successfully passaged a mouse-adapted strain of Sin Nombre virus from deer mice (Peromyscus maniculatus) by i.m. inoculation of 4- to 6-wk-old deer mouse pups. After inoculation with 5 ID(50), antibodies to the nucleocapsid (N) antigen first became detectable at 14 d whereas neutralizing antibodies were detectable by 7 d. Viral N antigen first began to appear in heart, lung, liver, spleen, and/or kidney… CONTINUE READING


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