Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis.

@article{Begg2010ExperimentalIM,
  title={Experimental infection model for Johne's disease using a lyophilised, pure culture, seedstock of Mycobacterium avium subspecies paratuberculosis.},
  author={Douglas J. Begg and Kumudika de Silva and Lyrissa Di Fiore and Deborah L. Taylor and Katrina L Bower and Ling Jian Zhong and Satoko Kawaji and David Emery and Richard J Whittington},
  journal={Veterinary microbiology},
  year={2010},
  volume={141 3-4},
  pages={
          301-11
        }
}
Johne's disease is a severe chronic enteritis of ruminants caused by Mycobacterium avium subspecies paratuberculosis (Map). Repeatable infections of known duration are required for validation of new diagnostic tests, evaluation of pathogenesis and development of improved vaccines. In the first study of its type, a standardised experimental model for Johne's disease was developed based on a lyophilised, low passage, pure culture, seedstock of Map. Experimental inoculations of sheep with… CONTINUE READING
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