Experimental immuno-alteration

@article{Lacy1984ExperimentalI,
  title={Experimental immuno-alteration},
  author={Paul E. Lacy},
  journal={World Journal of Surgery},
  year={1984},
  volume={8},
  pages={198-203}
}
  • P. Lacy
  • Published 1984
  • Medicine
  • World Journal of Surgery
AbstractIn the past few years, remarkable advances have been made in preventing rejection of islet allografts and xenografts (rat to mouse) by 6 procedures which do not involve continuous immunosuppressive therapy of recipient rodents. Four methods alter or destroy passenger lymphoid cells in the islets prior to transplantation. These include in vitro culture of donor rat islets at low temperature and a single injection of anti-lymphocyte serum in the recipients, culture of rat or mouse islet… Expand
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The replacement of endocrine tissue by transplantation could cure IDDM and perhaps prevent the development of complications, but a number of major problems arise in applying theoretical concepts to the practical clinical situation. Expand
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The rationale, methodology, and current results of islet allotransplantation are outlined, and the potential new developments that could enable this important treatment to be widely applicable to children are discussed. Expand
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The present situation in experimental and clinical diabetes is described, which means that with the exception of a few cases with transient function, islet transplantation has failed in man. Expand
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Canine islets in an ultrafiltered environment.
TLDR
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TLDR
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