Experimental hyperphenylalaninemia provokes oxidative stress in rat brain.

@article{Hagen2002ExperimentalHP,
  title={Experimental hyperphenylalaninemia provokes oxidative stress in rat brain.},
  author={Martine E Kienzle Hagen and Carolina Didonet Pederzolli and Angela Malysz Sgaravatti and Raquel Bridi and Moacir Wajner and Cl{\'o}vis Milton Duval Wannmacher and Angela T. S. Wyse and Carlos Severo Dutra-Filho},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1586 3},
  pages={
          344-52
        }
}
Tissue accumulation of L-phenylalanine (Phe) is the biochemical hallmark of human phenylketonuria (PKU), an inherited metabolic disorder clinically characterized by mental retardation and other neurological features. The mechanisms of brain damage observed in this disorder are poorly understood. In the present study we investigated some oxidative stress parameters in the brain of rats with experimental hyperphenylalaninemia. Chemiluminescence, total radical-trapping antioxidant potential (TRAP… CONTINUE READING
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