Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function.

@article{Samuelsson2013ExperimentalHI,
  title={Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function.},
  author={Anne-Maj Samuelsson and James Clark and Olena Rudyk and Michael J. Shattock and Sung Eun Bae and Timothy South and Joaquim Pombo and Kathrine L. Redington and Esna Uppal and Clive W. Coen and Lucilla Poston and Paul D Taylor},
  journal={Hypertension},
  year={2013},
  volume={62 3},
  pages={
          627-33
        }
}
The prevalence of obesity among pregnant women is increasing. Evidence from human cohort studies and experimental animals suggests that offspring cardiovascular and metabolic function is compromised through early life exposure to maternal obesity. Previously, we reported that juvenile offspring of obese rats develop sympathetically mediated hypertension associated with neonatal hyperleptinemia. We have now addressed the hypothesis that neonatal exposure to raised leptin in the immediate… CONTINUE READING

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