Experimental gram-negative bacterial sepsis: prevention of mortality not preventable by antibiotics alone.

@article{Greisman1979ExperimentalGB,
  title={Experimental gram-negative bacterial sepsis: prevention of mortality not preventable by antibiotics alone.},
  author={S E Greisman and J B DuBuy and Carol Woodward},
  journal={Infection and immunity},
  year={1979},
  volume={25 2},
  pages={538-57}
}
Outbred Swiss mice were inoculated intraperitoneally or intravenously with one 90 to 100% lethal dose of Escherichia coli O:18, Proteus mirabilis, or Klebsiella pneumoniae. After carefully timed intervals, aminoglycoside antibiotics were begun at dosages nnd intervals predetermined to constitute optimal therapy. With progressive increases in delay of antibiotic therapy, mortality rates increased progressively from 0% to 90 to 100%. Standardized models of infection were developed by selecting… CONTINUE READING