Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine.

@article{Hare2009ExperimentalGE,
  title={Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine.},
  author={William A. Hare and Larry Wheeler},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 6},
  pages={2940-8}
}
PURPOSE Excessive activity of NMDA-type (N-methyl-d-aspartate) glutamatergic channels has been implicated as a mechanism for neuronal injury in neurologic disorders, including glaucoma, and retinal disease. This study was designed to characterize the retinal response to experimental manipulations that mimic features of glutamatergic excitotoxic insult and also to determine whether memantine, an NMDA-type glutamatergic channel blocker, is effective in reversing experimental excitotoxicity… CONTINUE READING