Experimental factors affecting the quality and reproducibility of MALDI TOF mass spectra obtained from whole bacteria cells.

@article{Williams2003ExperimentalFA,
  title={Experimental factors affecting the quality and reproducibility of MALDI TOF mass spectra obtained from whole bacteria cells.},
  author={Tracie L. Williams and Denis Andrzejewski and Jackson O. Lay and Steven M. Musser},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2003},
  volume={14 4},
  pages={342-51}
}
Numerous experimental factors are shown to significantly influence the spectra obtained when bacteria are analyzed by MALDI TOF/MS. Detailed investigation of the instrument parameters and sample preparation are all shown to influence the spectra. Of these, the preanalysis sample preparation steps incorporate the most important elements influencing the quality and reproducibility of the spectra. Some of the most important sample preparation factors include the method employed for sterilization… CONTINUE READING
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