Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: generation of IL-10 and induction of regulatory T cells.

@article{Maeda2008ExperimentalEP,
  title={Experimental extracorporeal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms: generation of IL-10 and induction of regulatory T cells.},
  author={Akira Maeda and Agatha Schwarz and Ann Bullinger and Akimichi Morita and David Peritt and Thomas Vernon Schwarz},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={
          5956-62
        }
}
Extracorporeal photopheresis (ECP) is used to treat immune-mediated diseases including transplant rejection and graft-vs-host-disease. An experimental murine model of ECP utilizing contact hypersensitivity (CHS) revealed that ECP inhibits the sensitization of CHS and induces regulatory T cells (Treg). In this study, we find that ECP inhibits not only the sensitization but also the effector phase of CHS, although Treg only inhibited sensitization. IL-10 was determined to be a critical component… CONTINUE READING

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