Experimental evolution and the dynamics of genomic mutation rate modifiers

@article{Raynes2014ExperimentalEA,
  title={Experimental evolution and the dynamics of genomic mutation rate modifiers},
  author={Yevgeniy Raynes and Paul Sniegowski},
  journal={Heredity},
  year={2014},
  volume={113},
  pages={375-380}
}
Because genes that affect mutation rates are themselves subject to mutation, mutation rates can be influenced by natural selection and other evolutionary forces. The population genetics of mutation rate modifier alleles has been a subject of theoretical interest for many decades. Here, we review experimental contributions to our understanding of mutation rate modifier dynamics. Numerous evolution experiments have shown that mutator alleles (modifiers that elevate the genomic mutation rate) can… CONTINUE READING
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