Experimental evolution, loss-of-function mutations, and “the first rule of adaptive evolution”

  title={Experimental evolution, loss-of-function mutations, and “the first rule of adaptive evolution”},
  author={Michael J. Behe},
  journal={The Quarterly Review of Biology},
  pages={419 - 445}
  • M. Behe
  • Published 1 December 2010
  • Biology
  • The Quarterly Review of Biology
Adaptive evolution can cause a species to gain, lose, or modify a function; therefore, it is of basic interest to determine whether any of these modes dominates the evolutionary process under particular circumstances. Because mutation occurs at the molecular level, it is necessary to examine the molecular changes produced by the underlying mutation in order to assess whether a given adaptation is best considered as a gain, loss, or modification of function. Although that was once impossible… 
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