Experimental evolution, loss-of-function mutations, and “the first rule of adaptive evolution”
@article{Behe2010ExperimentalEL, title={Experimental evolution, loss-of-function mutations, and “the first rule of adaptive evolution”}, author={M. Behe}, journal={The Quarterly Review of Biology}, year={2010}, volume={85}, pages={419 - 445} }
Adaptive evolution can cause a species to gain, lose, or modify a function; therefore, it is of basic interest to determine whether any of these modes dominates the evolutionary process under particular circumstances. Because mutation occurs at the molecular level, it is necessary to examine the molecular changes produced by the underlying mutation in order to assess whether a given adaptation is best considered as a gain, loss, or modification of function. Although that was once impossible… CONTINUE READING
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References
SHOWING 1-10 OF 105 REFERENCES
The spread of a beneficial mutation in experimental bacterial populations: the influence of the environment and genotype on the fixation of rpoS mutations
- Biology, Medicine
- Heredity
- 2008
- 54
- PDF
Bacterial evolution through the selective loss of beneficial Genes. Trade-offs in expression involving two loci.
- Biology, Medicine
- Genetics
- 2003
- 70
- PDF
In vivo molecular evolution reveals biophysical origins of organismal fitness.
- Biology, Medicine
- Molecular cell
- 2006
- 103
Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2008
- 640
- PDF
Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1994
- 854
- PDF
Tests of parallel molecular evolution in a long-term experiment with Escherichia coli.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2006
- 294
- PDF
Long-Term Experimental Evolution in Escherichia coli. XII. DNA Topology as a Key Target of Selection
- Biology, Medicine
- Genetics
- 2005
- 130
- PDF
Predicting evolution from genomics: experimental evolution of bacteriophage T7
- Medicine, Biology
- Heredity
- 2008
- 43
- PDF