Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency

  title={Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency},
  author={Terry G. J. Derks and Catharina M. L. Touw and Graziela Schmitt Ribas and Giovana Brondani Biancini and Camila Simioni Vanzin and Giovanna Webster Negretto and Caroline Paula Mescka and Dirk-Jan Reijngoud and G. Peter A. Smit and Moacir Wajner and Carmen Regla Vargas},
  journal={Journal of Inherited Metabolic Disease},
The objective of this study was to test whether macromolecule oxidative damage and altered enzymatic antioxidative defenses occur in patients with medium-chain acyl coenzyme A dehydrogenase (MCAD) deficiency. We performed a cross-sectional observational study of in vivo parameters of lipid and protein oxidative damage and antioxidant defenses in asymptomatic, nonstressed, MCAD-deficient patients and healthy controls. Patients were subdivided into three groups based on therapy: patients without… 

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