Experimental evidence for major histocompatibility complex-allele-specific resistance to a bacterial infection.

@article{Lohm2002ExperimentalEF,
  title={Experimental evidence for major histocompatibility complex-allele-specific resistance to a bacterial infection.},
  author={Jakob Lohm and Mats Grahn and Asa Langefors and \Oivind Andersen and Arne Storset and Torbj{\"o}rn von Schantz},
  journal={Proceedings. Biological sciences},
  year={2002},
  volume={269 1504},
  pages={2029-33}
}
The extreme polymorphism found at some major histocompatibility complex (MHC) loci is believed to be maintained by balancing selection caused by infectious pathogens. Experimental support for this is inconclusive. We have studied the interaction between certain MHC alleles and the bacterium Aeromonas salmonicida, which causes the severe disease furunculosis, in Atlantic salmon (Salmo salar L.). We designed full-sibling broods consisting of combinations of homozygote and heterozygote genotypes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

Similar Papers

Loading similar papers…