Experimental evidence for an alternative to directed mutation in thebgl operon

@article{Mittler1992ExperimentalEF,
  title={Experimental evidence for an alternative to directed mutation in thebgl operon},
  author={John E. Mittler and Richard E. Lenski},
  journal={Nature},
  year={1992},
  volume={356},
  pages={446-448}
}
THE directed mutation hypothesis1–6 suggests that some mutations occur more often when selectively advantageous than when neutral or disadvantageous, challenging the principle that the selective value of a mutation does not affect the rate of its occurrence7–11. Mutations in the bgl operon ofEscherichia coli have been reported to be a case of directed mutation2. E. coli K12 strain Ξ342LD cannot grow on salicin but derivatives with two mutations in the bgl operon, an excision of IS 150 (formally… CONTINUE READING

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