Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

@inproceedings{Nishikiori2008ExperimentalEO,
  title={Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy},
  author={Nami Nishikiori and Makoto Osanai and Hideki Chiba and Takashi Kojima and Shuichiro Inatomi and Hiroshi Ohguro and Norimasa Sawada},
  booktitle={Clinical ophthalmology},
  year={2008}
}
PURPOSE This study was conducted to investigate whether retinoic acids (RAs) had any effect on apoptosis during the development of diabetic retinopathy. METHODS To investigate whether RAs had any effect on apoptosis during the development of diabetic retinopathy, we housed 32 C57BL/6 male mice and induced diabetes in 24 by intra peritoneal injections of streptozotocin (STZ; Sigma, St Louis, MO) and treated 16 of the diabetic mice with the RAs, all-trans-retinoic acid (ATRA) (seven mice) and 4… CONTINUE READING
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