Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.

@article{ElRemessy2003ExperimentalDC,
  title={Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.},
  author={Azza B. El-Remessy and Mohamed Ali Behzadian and Gamal Abou-Mohamed and Telina Franklin and Robert W. Caldwell and Ruth B. Caldwell},
  journal={The American journal of pathology},
  year={2003},
  volume={162 6},
  pages={
          1995-2004
        }
}
The purpose of these experiments was to determine the specific role of reactive oxygen species (ROS) in the blood-retinal barrier (BRB) breakdown that characterizes the early stages of vascular dysfunction in diabetes. Based on our data showing that high glucose increases nitric oxide, superoxide, and nitrotyrosine formation in retinal endothelial cells, we hypothesized that excess formation of ROS causes BRB breakdown in diabetes. Because ROS are known to induce increases in expression of the… Expand
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