Experimental determination of the evolvability of a transcription factor.


Sequence-specific binding of a transcription factor to DNA is the central event in any transcriptional regulatory network. However, relatively little is known about the evolutionary plasticity of transcription factors. For example, the exact functional consequence of an amino acid substitution on the DNA-binding specificity of most transcription factors is… (More)
DOI: 10.1073/pnas.0907688106


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