Experimental determination and prediction of the fitness effects of random point mutations in the biosynthetic enzyme HisA.

Abstract

The distribution of fitness effects (DFE) of mutations is a factor of fundamental importance in evolutionary biology. We determined the DFE of 510 mutants that each carried between 1 to 10 mutations (synonymous and non-synonymous) in the hisA gene, encoding an essential enzyme in the L-histidine biosynthesis pathway of Salmonella enterica. For the full set… (More)
DOI: 10.1093/molbev/msx325

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