Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins.

  title={Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins.},
  author={S H Chen and Weidong Le and Wan Jun Xie and Maria E Alexianu and J{\'o}zsef I. Engelhardt and L{\'a}szl{\'o} Sikl{\'o}s and Stanley H. Appel},
  journal={Archives of neurology},
  volume={55 8},
BACKGROUND Increased levels of free radicals and oxidative stress may contribute to the pathogenesis of substantia nigra (SN) injury in Parkinson disease (PD), but the initiating etiologic factors remain undefined in most cases. OBJECTIVE To determine the potential importance of immune mechanisms in triggering or amplifying neuronal injury, we assayed serum samples from patients with PD to determine the ability of IgG to initiate relatively specific SN injury in vivo. METHODS IgG purified… CONTINUE READING


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