Experimental design for fermentation media development: statistical design or global random search?

@article{WeusterBotz2000ExperimentalDF,
  title={Experimental design for fermentation media development: statistical design or global random search?},
  author={Dirk Weuster-Botz},
  journal={Journal of bioscience and bioengineering},
  year={2000},
  volume={90 5},
  pages={
          473-83
        }
}
The diversity of combinatorial interactions of medium components with the metabolism of cells as well as the large number of medium constituents necessary for cellular growth and production do not permit satisfactory detailed modelling. For this reason, experimental search procedures in simultaneous shaking flask experiments are used to optimise fermentation media. As an alternative to the methods of statistical experimental design employed in this field for many decades, the use of stochastic… CONTINUE READING

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