Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM.

@article{Flassig2014ExperimentalDV,
  title={Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM.},
  author={Robert J. Flassig and Gunter Maubach and Christian T{\"a}ger and Kai Sundmacher and Michael Naumann},
  journal={Molecular bioSystems},
  year={2014},
  volume={10 7},
  pages={1978-86}
}
Reliable and efficient detection of DNA damage constitutes a vital capability of human cells to maintain genome stability. Following DNA damage, the histone variant H2AX becomes rapidly phosphorylated by the DNA damage response kinases DNA-PKcs and ATM. H2AX phosphorylation plays a central role in signal amplification leading to chromatin remodeling and DNA… CONTINUE READING