Experimental control of cardiac muscle alternans.

  title={Experimental control of cardiac muscle alternans.},
  author={Glenn L. Martin Hall and Daniel J. Gauthier},
  journal={Physical review letters},
  volume={88 19},
We demonstrate that alternans in small pieces of in vitro paced bullfrog (Rana Catesbeiana) myocardium can be suppressed by making minute adjustments to the pacing period in response to real time measurements of the action potential duration. Control is possible over a large range of physiological conditions over many animals and the self-referencing control protocol can automatically adjust to changes in the pacing interval. Our results suggest the feasibility of developing low-energy methods… CONTINUE READING
Highly Cited
This paper has 89 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Studies on feedback control of cardiac alternans

Computers & Chemical Engineering • 2008
View 4 Excerpts
Highly Influenced

Suppression of cardiac altemans by the alternating-period feedback control

2016 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES) • 2016
View 1 Excerpt

89 Citations

Citations per Year
Semantic Scholar estimates that this publication has 89 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 12 references


J.E.S. Socolar, D. J. Gauthier
Rev. E 57, 6589 • 1998
View 7 Excerpts
Highly Influenced


J. B. Nolasco, R. W. Dahlen, J. Appl
25, 191 • 1968
View 4 Excerpts
Highly Influenced


V. N. Biktashev, A. V. Holden
R. Soc. London B 261, 211 (1995); L. Glass and M. E. Josephson, Phys. Rev. Lett. 75, 2059 (1995); M. Watanabe and R. F. Gilmour, Jr., J. Math. Biol. 35, 73 (1996); D. J. Christini and J. J. Collins, Phys. Rev. E 53, R49 (1996); W. J. Rappel, F. Fenton, and A. Karma, Phys. Rev. Lett. 83, 456 (1999); • 2001
View 1 Excerpt


G. M. Hall, S. Bahar, D. J. Gauthier
Rev. Lett. 82, 2995 • 1999


L. Glass
Today 49, No. 8, 40 (1996); A. T. Winfree, Chaos 8, 1 (1998); F. X. Witkowski et al., Nature (London) 392, 78 (1998); R. A. Gray, A. M. Pertsov, and J. Jalife, Nature (London) 392, 75 • 1998

Chaos 4

A. Karma
461 (1994); N. A. M. Estes et al., Am. J. Cardiol. 80, 1314 • 1997
View 1 Excerpt


D. J. Gauthier, J.E.S. Socolar
Rev. Lett. 79, 4938 • 1997

Nature (London) 363

T. Shinbrot, C. Grebogi, E. Ott, J. A. Yorke
411 • 1993
View 2 Excerpts

Science 257

A. Garfinkel, M. L. Spano, W. L. Ditto, J. L. Weiss
1230 • 1992
View 1 Excerpt


D. R. Chialvo, D. C. Michaels, J. Jalife
Res. 66, 525 • 1990
View 1 Excerpt