Experimental colonic healing in relation to timing of 5-fluorouracil therapy.

@article{Weiber1994ExperimentalCH,
  title={Experimental colonic healing in relation to timing of 5-fluorouracil therapy.},
  author={S Weiber and Wilhelm Graf and Bengt Glimelius and H A Jiborn and Lars A P{\aa}hlman and B H Zederfeldt},
  journal={The British journal of surgery},
  year={1994},
  volume={81 11},
  pages={1677-80}
}
In an experimental study resembling clinical use of adjuvant 5-fluorouracil (5-FU) treatment of colorectal carcinoma, 97 male Wistar rats were operated on with a standardized left colonic resection. Treatment was given as a daily intraperitoneal injection. The animals were randomized to one of four groups: early treatment with 5-FU 20 mg/kg or saline 0.1 mol/l from the day of operation to day 7 after operation, and delayed treatment with 5-FU 20 mg/kg or saline 0.1 mol/l from the third day… CONTINUE READING
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