Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways.

  title={Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways.},
  author={Kenneth Lamb and Fang Zhong and Gerald F. Gebhart and Klaus Bielefeldt},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={290 3},
Chronic pain syndromes affecting different organs often coexist. We hypothesized that sensitization of one afferent pathway may affect converging input from other areas of the body. We induced colitis in mice with 2,4,6-trinitrobenzenesulfonic acid (TNBS); control animals were treated with equal volumes of vehicle (50% ethanol) only. Visceromotor responses to graded colorectal distension, cystometrograms, and response thresholds to mechanical and thermal stimulation of both hind paws were… 

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