Corpus ID: 13552335

Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani.

@article{Wabwoba2010ExperimentalCW,
  title={Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani.},
  author={Byrum W Wabwoba and C. Anjili and M. Ngeiywa and P. Ngure and E. Kigondu and J. Ingonga and J. Makwali},
  journal={Journal of vector borne diseases},
  year={2010},
  volume={47 3},
  pages={
          160-7
        }
}
BACKGROUND & OBJECTIVES Several plant products have been tested and found to possess antileishmanial activity. The present study was undertaken to establish whether methanolic extract of Allium sativum Linn has antileishmanial activity in comparison to standard drugs. METHODS Methanolic extract of A. sativum bulbs was screened for in vitro and in vivo antileishmanial activity against Leishmania major strain (NLB 145) and L. donovani strain (NLB 065). Pentostam and Amphotericin B were used as… Expand
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TLDR
Water and methanolic plant extracts significantly inhibited the growth of Leishmania major parasites as compared to amphotericin B with respect to the parasite infection rates and MIC levels. Expand
Efficacy of combination therapy using extracts of Aloe secundiflora Eng L and Callistemon citrinus William C. in Leishmania major infected BALB/c mice
TLDR
The combination therapy was active against L. major parasite, reduced lesion size significantly and did not prevent visceralisation but reduced spleen parasite load significantly. Expand
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