Experimental chemotherapy of filariasis: comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi.

@article{Zahner1993ExperimentalCO,
  title={Experimental chemotherapy of filariasis: comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi.},
  author={Horst Zahner and Gereon Schares},
  journal={Acta tropica},
  year={1993},
  volume={52 4},
  pages={
          221-66
        }
}

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TLDR
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Effects of albendazole on Litomosoides chagasfilhoi (Nematoda: Filarioidea) females in vivo

TLDR
The present study contributes to the knowledge of albendazole’s effects in filariids and demonstrates the potential embryotoxic and microfilaricidal consequences of this drug.

Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial/anthelmintic activity.

TLDR
This review focuses on the plant products reported to be useful in the control and treatment of human helminth infections with the main emphasis on filariasis and the in vitro and in vivo systems available for assaying anthelmintic activity.

Lethal LPS-independent side effects after microfilaricidal treatment in Acanthocheilonema viteae-infected rodents

TLDR
The data show that adverse effects after effectivemicrofilaricidal therapy may be caused by microfilariae derived components different from Wolbachia-released LPS.

References

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Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 2. The activity of drugs against microfilariae.

Comparative investigations of the chemotherapeutic activity of various filaricidal compounds and other anthelmintics were made with Litomosoides carinii infections in Mastomys natalensis, special

Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections.

TLDR
Amoscanate exhibited superiority over the benzimidazoles in that the compound eliminated microfilariae and adult worms of both L. carinii and B. pahangi species when given by oral and subcutaneous routes.

Antifilarial activities of benzazole derivatives. 3. Effects of benzothiazoles on third stage larvae and preadult worms of Acanthocheilonema viteae, Brugia malayi and B. pahangi in Mastomys natalensis.

  • H. ZahnerH. StriebelI. SängerH. Schütze
  • Biology
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit
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Ten structurally defined benzothiazoles (5-methyl and the analogous 5-methoxy derivatives) with known macrofilaricidal and microfilaricidal activities were tested for efficacy against third stage

Antifilarial activities of benzazole derivatives. 2. Microfilaricidal effects against Litomosoides carinii, Acanthocheilonema. vitae, Brugia malayi and B. pahangi in Mastomys natalensis.

TLDR
The spectrum of antimicrofilarial activities of eighteen 2-tertbutylbenzazole derivatives was evaluated comparatively in Mastomys natalensis infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi or B. pahangi and all compounds were effective against the microfilariae of all 4 species.

Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 6. The filaricidal activity of organophosphorus compounds.

TLDR
The anthelmintic haloxon proved to be the most effective compound with high activity against microfilariae and a favourable chemotherapeutic range and the organophosphorus compounds did not show any influence on the mobility or viability of the adult worms of Litomosoides carinii.

Chemotherapy of filariasis in squirrel monkeys (Saimiri sciureus).

TLDR
Dithiazanine iodide proved to be unsuitable for use because of lack of acceptance by the monkeys, and diethylcarbamazine was found to be effective against both microfilaria and adults of all filarial species tested.

Chemotherapy of Onchocerca lienalis microfilariae in mice: a model for the evaluation of novel compounds for the treatment of onchocerciasis

TLDR
This mouse model has value as an additional drug screen for onchocerciasis, which will enable the evaluation of novel compounds against skin-dwelling Onchocerca mf at the primary/secondary level, providing complementary information to new in vitro screens using adult Onchokerca.

The anthelmintic effects of albendazole on Brugia pahangi

TLDR
Albendazole is a potent macrofilaricide against Brugia pahangi and can be seen that 5 X 50 mg ALBZ/kg was 100% effective in killing the adult worm.

Comparative susceptibility to anthelmintics of Brugia pahangi in jirds infected by different methods

TLDR
Comparison of the activity of 9 macrofilaricidal compounds against Brugia pahangi by three methods found that mebendazole and albendazoles were more active against implanted adults than against L3 induced adults in the peritoneal cavity.

Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 7. Filaricidal activity of furazolidone.

TLDR
Investigations were carried out on the filaricidal activity of furazolidone against Litomosoides carinii infection in Mastomys natalensis and found all the adult parasites were killed within two weeks of the start of treatment.
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