Experimental chemonucleolysis with recombinant human matrix metalloproteinase 7 in human herniated discs and dogs.

@article{Haro2014ExperimentalCW,
  title={Experimental chemonucleolysis with recombinant human matrix metalloproteinase 7 in human herniated discs and dogs.},
  author={Hirotaka Haro and Miyuki Nishiga and Daisuke Ishii and Takasumi Shimomoto and Tsuyoshi Kato and Osami Takenouchi and Satoshi Koyanagi and Tetsuro Ohba and Hiromichi Komori},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2014},
  volume={14 7},
  pages={1280-90}
}
BACKGROUND CONTEXT Chemonucleolysis has been proposed as a less invasive technique than surgery for patients with lumbar disc herniation. Once chymopapain had been approved as a chemonucleolysis drug, it was withdrawn because of serious complications. A novel agent with fewer complications would be desirable. PURPOSE The purpose of this study was to investigate the effects of recombinant human matrix metalloproteinase 7 (rhMMP-7) in experimental chemonucleolysis in vitro and in vivo and… CONTINUE READING
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