Experimental cataracts in rats due to tryptophan-free diet

@article{Ohrloff1978ExperimentalCI,
  title={Experimental cataracts in rats due to tryptophan-free diet},
  author={Christian Ohrloff and Charles Stoffel and Hans -Reinhard Koch and Ulrich Wefers and Johan Bours and Otto Hockwin},
  journal={Albrecht von Graefes Archiv f{\"u}r klinische und experimentelle Ophthalmologie},
  year={1978},
  volume={205},
  pages={73-79}
}
A Tryptophan-free diet induces posterior subcapsular cataracts and reversible corneal opacities in young Wistar rats. Compared to the controls there is a significant decrease of body weight, lens fresh weight, and water-soluble lens protein. Protein separation by isoelectric focusing shows diminished α-, β-, and γ-crystallin fractions. If tryptophan is restored to the diet after 24 days, new clear lens fibers are laid down again, indicating that the mechanism of protein synthesis has not been… CONTINUE READING

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