Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation.

@article{Golino1992ExperimentalCS,
  title={Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation.},
  author={Paolo Golino and Giuseppe Ambrosio and I Pascucci and Massimo Ragni and E Russolillo and Massimo Chiariello},
  journal={Thrombosis and haemostasis},
  year={1992},
  volume={67 3},
  pages={
          302-5
        }
}
Previous studies have shown that experimental canine coronary artery stenosis associated with endothelial injury results in a typical pattern of coronary flow characterized by gradual decreases in coronary flow to almost zero values followed by restorations of flow to normal values. This pattern of flow, called cyclic flow reductions (CFRs), is the consequence of recurrent platelet aggregation at the site of the stenosis and endothelial injury and subsequent dislodgement of the thrombus. In the… 
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