Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history

@article{Diguet2004ExperimentalBF,
  title={Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history},
  author={Elsa Diguet and Pierre-Olivier Fernagut and Elisabeth Normand and Laurie Centelles and Christophe Mulle and Francois Tison},
  journal={Neurobiology of Disease},
  year={2004},
  volume={15},
  pages={667-675}
}
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17 Citations
Background Citations
8
Results Citations
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17 Citations

Citation Type

Citation Type

Genetic analysis of the GRIK2 modifier effect in Huntington's disease
TLDR
Haplotype analysis using microsatellites, known SNPs and new variants discovered in the 3'UTR argues against a common ancestral origin for the 16 TAA repeat alleles in individuals who showed much earlier age at neurological onset than would be expected from the length of their HD CAG mutation.
Huntington’s Disease: Relationship Between Phenotype and Genotype
TLDR
The recent advancement on the genotype-phenotype relationship of HD is reviewed, mainly focus on the characteristics of different expanded CAG repeat number, genetic modifiers, and CCG repeat number in the 3′ end of CAG triplet repeat and their effects on the phenotype.
Oxidative damage in Huntington's disease pathogenesis.
TLDR
Current evidence supporting a role for oxidative damage in the etiology of neuronal damage and degeneration in Huntington's disease is reviewed.
Polymorphism of the glutamate receptor genes and risk of paranoid schizophrenia in Russians and Tatars from the Republic of Bashkortostan
TLDR
The hypothesis that glutamate receptor genes are involved in the etiology and pathogenesis of schizophrenia and response to haloperidol treatment is supported.
Emerging drug therapies in Huntington's disease
TLDR
This review discusses the treatments now used for Huntington's disease before evaluating the newer drugs at present being explored in both the clinic and in the laboratory in mouse models of the disease.
Emergingdrugtherapiesin Huntington'sdisease
TLDR
This review discusses the treatments now used for Huntington's disease before evaluating the newer drugs at present being explored in both the clinic and in the laboratory in mouse models of the disease.
Kainate Receptors in Health and Disease
Kainate receptors in epilepsy and excitotoxicity
Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms
TLDR
It is demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA Formation in KD.
Genetic modifiers of Huntington's disease
TLDR
Advances in genetic technology are expected to highlight processes capable of altering the course of HD and therefore to provide new, human‐validated targets for traditional drug development, with the goal of developing rational treatments to delay or prevent onset of HD clinical signs.
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References

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TLDR
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TLDR
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