Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization.

@article{Caspi1990ExperimentalAU,
  title={Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization.},
  author={Rachel R Caspi and Chi Chao Chan and W C Leake and Masaru Higuchi and Barbara N Wiggert and Gerald J. Chader},
  journal={Journal of autoimmunity},
  year={1990},
  volume={3 3},
  pages={237-46}
}
Experimental autoimmune uveoretinitis (EAU) in the mouse is a recently developed model of ocular autoimmunity. Dependence of disease induction on qualitative and quantitative parameters of immunization was studied in B10.A mice immunized with interphotoreceptor retinoid-binding protein (IRBP). It was found that use of Bordetella pertussis adjuvant as well as its mode of preparation was of critical importance for disease induction; no disease was induced if pertussis adjuvant was omitted. The… CONTINUE READING
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