Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

@article{Griffin1995ExperimentalAI,
  title={Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.},
  author={A. Clark Griffin and Weiming Zhao and Keith W. Wegmann and W F Hickley},
  journal={The American journal of pathology},
  year={1995},
  volume={147 3},
  pages={845-57}
}
Type I diabetes, an autoimmune disease that occurs in humans and animals, is characterized by the destruction of insulin-secreting islet beta-cells of the pancreas. Antibodies directed toward multiple islet protein can be detected before diagnosis of type I diabetes; however, the identity of the inciting autoantigen(s) that targets beta-cells for destruction has not been defined. Autorecognition of many self-proteins by CD4+ T lymphocytes is restricted by the products of class II immune… CONTINUE READING