Experimental atherosclerosis in rabbits: platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin.

Abstract

Experimental atherosclerosis in rabbits was associated with increased aggregation of their platelets to arachidonic acid, and with increased generation of thromboxane A2 by their platelet-rich plasma. A heightened susceptibility of platelets to the anti-aggregatory action of prostacyclin against the ADP-induced aggregation was also observed. It is concluded that in advance atherosclerosis the platelet system is hypersensitive to biologically active metabolites of arachidonic acid.

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@article{Zmuda1977ExperimentalAI, title={Experimental atherosclerosis in rabbits: platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin.}, author={Andy Zmuda and Aldona Dembińska-Ki{\'e}c and A Chytkowski and Ryszard Jerzy Gryglewski}, journal={Prostaglandins}, year={1977}, volume={14 6}, pages={1035-42} }