Experimental approaches for the discovery and characterization of regulatory small RNA.

@article{Sharma2009ExperimentalAF,
  title={Experimental approaches for the discovery and characterization of regulatory small RNA.},
  author={Cynthia M. Sharma and J{\"o}rg Vogel},
  journal={Current opinion in microbiology},
  year={2009},
  volume={12 5},
  pages={536-46}
}
Following the pioneering screens for small regulatory RNAs (sRNAs) in Escherichia coli in 2001, sRNAs are now being identified in almost every branch of the eubacterial kingdom. Experimental strategies have become increasingly important for sRNA discovery, thanks to increased availability of tiling arrays and fast progress in the development of high-throughput cDNA sequencing (RNA-Seq). The new technologies also facilitate genome-wide discovery of potential target mRNAs by sRNA pulse-expression… CONTINUE READING

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