Experimental appraisal of the lack of antitumor natural killer cell-mediated immunosurveillance in response to lymphomas growing in the mouse brain.

@article{Yamasaki2003ExperimentalAO,
  title={Experimental appraisal of the lack of antitumor natural killer cell-mediated immunosurveillance in response to lymphomas growing in the mouse brain.},
  author={Toshiki Yamasaki and Kouzo Moritake and George DeV. Klein},
  journal={Journal of neurosurgery},
  year={2003},
  volume={98 3},
  pages={
          599-606
        }
}
OBJECT Natural killer (NK) cell-mediated immunosurveillance in the brain is currently obscure, in contrast with the intracerebral immune reaction of cytotoxic T lymphocytes (CTLs) to tumor cells. The goal of this study, in which a controlled tumor model was used, was to investigate a relationship between NK cells and major histocompatibility complex (MHC) Class I gene expression in intracerebral tumor-bearing hosts. METHODS A matched set of two cloned tumor cell lines (lymphoma+ and lymphoma… CONTINUE READING
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