Experimental anxiety and the reinforcing effects of ethanol in rats.

  title={Experimental anxiety and the reinforcing effects of ethanol in rats.},
  author={Solange L{\'u}cia Blatt and Reinaldo Naoto Takahashi},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  volume={32 4},
In order to examine the relationship between anxiety and reinforcing effects of alcohol, drug-naive male Wistar rats weighing 250-300 g were classified as "anxious" and "non-anxious" in the elevated plusmaze test. A conditioned place preference test was then used to investigate the reinforcing effects of ethanol (EtOH) on these animals. On 2 alternate days, groups of "anxious", "non-anxious" and "normal" rats received intraperitoneal (i.p.) injections of EtOH (0.5, 1.0 or 1.5 g/kg) immediately… CONTINUE READING

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