Experimental antitumor activity of BMY-28090, a new antitumor antibiotic

  title={Experimental antitumor activity of BMY-28090, a new antitumor antibiotic},
  author={J. Schurig and W. T. Bradner and G. Basler and W. Rose},
  journal={Investigational New Drugs},
SummaryBMY-28090 is a novel actinomycete fermentation derived antitumor agent. The cytotoxic effect of BMY-28090 was evaluated in two murine and eight human tumor cell lines in vitro. Following 72-hour exposures, BMY-28090 was cytotoxic for all of these cell lines with IC50 values of < 0.02 to 3.25 μg/ml. BMY-28090 was evaluated for in vivo antitumor activity in a variety of experimental murine tumor and human tumor xenograft models. Initial testing against the murine tumor models was performed… Expand


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