Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies.

@article{Galvo1997ExperimentalAM,
  title={Experimental animal model of graft-versus-host disease (GVHD) after small-bowel transplantation: characteristics of the model and application to developing treatment strategies.},
  author={Fl{\'a}vio Henrique Ferreira Galv{\~a}o and Qifa Ye and C S Doughton and Noriko Murase and Satoru Todo and Adriana Zeevi and Dan Linetzky Waitzberg and John J. Fung and Thomas E. Starzl},
  journal={Transplantation proceedings},
  year={1997},
  volume={29 1-2},
  pages={700}
}
ALTHOUGH graft-versus-host disease (GVHD) has been a major concern after small-bowel transplantation (SBTX), the lack of suitable experimental model has allowed only limited study of GVHD after solid-organ transplantation. l We recently developed a clinically relevant experimental animal model of GVHD of fully allogeneic SBTX. This study describes histopathological evolution of the disease. cytokine involvement, responsible donor cells, and preliminary results of treatment using recipient and… CONTINUE READING