Experimental and theoretical study of mitotic spindle orientation

@article{Thry2007ExperimentalAT,
  title={Experimental and theoretical study of mitotic spindle orientation},
  author={Manuel Th{\'e}ry and A. Jim{\'e}nez-Dalmaroni and V. Racine and M. Bornens and F. J{\"u}licher},
  journal={Nature},
  year={2007},
  volume={447},
  pages={493-496}
}
The architecture and adhesiveness of a cell microenvironment is a critical factor for the regulation of spindle orientation in vivo. Using a combination of theory and experiments, we have investigated spindle orientation in HeLa (human) cells. Here we show that spindle orientation can be understood as the result of the action of cortical force generators, which interact with spindle microtubules and are activated by cortical cues. We develop a simple physical description of this spindle… Expand
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