Experimental and modelistic approach to explain granulate inhomogeneity through preferential growth.

Abstract

Wet granulation of a powder mixture often leads to accumulation of the smallest particles in the large granules. The preferential uptake of these particles results in an inhomogeneous granulate. The aim of this study was to investigate the mechanism of preferential growth. For that purpose the growth of one single granule was followed by adding a droplet of… (More)

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@article{Dries2003ExperimentalAM, title={Experimental and modelistic approach to explain granulate inhomogeneity through preferential growth.}, author={Kaspar van den Dries and Herman Vromans}, journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, year={2003}, volume={20 4-5}, pages={409-17} }