Experimental analysis of risk factors for ulcerative dermatitis in mice.

  title={Experimental analysis of risk factors for ulcerative dermatitis in mice.},
  author={Brit Neuhaus and C. Niessen and Andrea Mesaros and Dominic J. Withers and Thomas Krieg and Linda Partridge},
  journal={Experimental dermatology},
  volume={21 9},
Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to be fully resistant to UD. In this study, we showed that high-fat diet (HFD) feeding significantly increased incidence of UD in wild type (WT) C57BL/6 mice, as did lithium-mediated inhibition of GSK3-β, which is a key negative regulator of IRS1. In contrast to WT mice, resistance to UD was fully preserved in HFD-fed Irs1-KO mice. Our results… CONTINUE READING

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