Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse.

  title={Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse.},
  author={Mark Stephen Lever and Michelle R. Nelson and Philip I Ireland and Anthony J Stagg and Richard J Beedham and Graham Hall and Georgina Knight and Richard W. Titball},
  journal={Journal of medical microbiology},
  volume={52 Pt 12},
The object of this study was to develop and characterize experimental Burkholderia mallei aerosol infection in BALB/c mice. Sixty-five mice were infected with 5000 [approx. 2.5 median lethal doses (MLD)] B. mallei strain ATCC 23344(T) bacteria by the aerosol route. Bacterial counts within lung, liver, spleen, brain, kidney and blood over 14 days were determined and histopathological and immunocytochemical profiles were assessed. Mortality due to B. mallei infection occurred between days 4 and… CONTINUE READING