Experimental adaptation of Salmonella typhimurium to mice.

  title={Experimental adaptation of Salmonella typhimurium to mice.},
  author={Annika I Nilsson and Elisabeth Kugelberg and Otto G. Berg and Dan I Andersson},
  volume={168 3},
Experimental evolution is a powerful approach to study the dynamics and mechanisms of bacterial niche specialization. By serial passage in mice, we evolved 18 independent lineages of Salmonella typhimurium LT2 and examined the rate and extent of adaptation to a mainly reticuloendothelial host environment. Bacterial mutation rates and population sizes were… CONTINUE READING