Experimental acute sodium fluoride poisoning in sheep: renal, hepatic, and metabolic effects.

@article{Kessabi1985ExperimentalAS,
  title={Experimental acute sodium fluoride poisoning in sheep: renal, hepatic, and metabolic effects.},
  author={Mohammed Kessabi and A. Hamliri and J. P. Braun and Alvaro Rico},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1985},
  volume={5 6 Pt 1},
  pages={1025-33}
}
Sheep received a single intragastric dose of 0.5, 1.0, 1.5, or 2.0 mmol F-/kg. Mild signs occurred at 1.5 mmol F-/kg and the animals recovered 2 days later. With the 2.0 mmol F-/kg dose all animals showed dullness, anorexia, and mild diarrhea which decreased from the third day. Dose-related congestion of duodenum, liver, kidney, and lung was observed in all animals. For the two higher doses kidney degeneration and tubular necrosis were associated with glomerular inflammation. Serum fluoride had… CONTINUE READING

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