Experimental Vaccine Induces Th1-driven Immune Responses and Resistance to Neisseria gonorrhoeae Infection in a Murine Model

@inproceedings{Liu2017ExperimentalVI,
  title={Experimental Vaccine Induces Th1-driven Immune Responses and Resistance to Neisseria gonorrhoeae Infection in a Murine Model},
  author={Yingru Liu and Laura A. Hammer and Wen-sheng Liu and Marcia M. Hobbs and Ryszard A. Zielke and Aleksandra E Sikora and Ann E Jerse and Nejat K. Egilmez and Michael W. Russell},
  booktitle={Mucosal Immunology},
  year={2017}
}
Female mice were immunized intravaginally with gonococcal outer membrane vesicles (OMVs) plus microencapsulated interleukin-12 (IL-12), and challenged using an established model of genital infection with Neisseria gonorrhoeae. Whereas sham-immunized and control animals cleared the infection in 10–13 days, those immunized with OMV plus IL-12 cleared… CONTINUE READING