Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

@article{Connors2013ExperimentalTF,
  title={Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside},
  author={Nicholas J. Connors and Robert S. Hoffman},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={347},
  pages={251 - 257}
}
  • N. Connors, R. Hoffman
  • Published 1 November 2013
  • Biology
  • The Journal of Pharmacology and Experimental Therapeutics
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. Although there is no true antidote to cocaine toxicity, current management strategies address the life-threatening systemic effects, namely hyperthermia, vasospasm, and severe hypertension. Clinicians rely on rapid cooling, benzodiazepines, and α-adrenergic antagonists for management, with years of proven benefit. Experimental agents have been developed to more effectively treat acute toxicity… 

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