Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside
@article{Connors2013ExperimentalTF, title={Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside}, author={Nicholas J. Connors and Robert S. Hoffman}, journal={The Journal of Pharmacology and Experimental Therapeutics}, year={2013}, volume={347}, pages={251 - 257} }
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. Although there is no true antidote to cocaine toxicity, current management strategies address the life-threatening systemic effects, namely hyperthermia, vasospasm, and severe hypertension. Clinicians rely on rapid cooling, benzodiazepines, and α-adrenergic antagonists for management, with years of proven benefit. Experimental agents have been developed to more effectively treat acute toxicity…
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