Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside

@article{Connors2013ExperimentalTF,
  title={Experimental Treatments for Cocaine Toxicity: A Difficult Transition to the Bedside},
  author={N. Connors and R. Hoffman},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={347},
  pages={251 - 257}
}
  • N. Connors, R. Hoffman
  • Published 2013
  • Medicine
  • The Journal of Pharmacology and Experimental Therapeutics
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. Although there is no true antidote to cocaine toxicity, current management strategies address the life-threatening systemic effects, namely hyperthermia, vasospasm, and severe hypertension. Clinicians rely on rapid cooling, benzodiazepines, and α-adrenergic antagonists for management, with years of proven benefit. Experimental agents have been developed to more effectively treat acute toxicity… Expand
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References

SHOWING 1-10 OF 71 REFERENCES
Use of antipsychotics to treat cocaine toxicity?
The effect of olanzapine pretreatment on acute cocaine toxicity in mice
Therapeutic use of butyrylcholinesterase for cocaine intoxication.
Efficacy of a therapeutic cocaine vaccine in rodent models
Ziprasidone pretreatment attenuates the lethal effects of cocaine in a mouse model.
Ziprasidone, diazepam, or the combination for prevention of cocaine toxicity in a mouse model.
Amelioration of the Cardiovascular Effects of Cocaine in Rhesus Monkeys by a Long-Acting Mutant Form of Cocaine Esterase
Mechanism of Cocaine-Induced Hyperthermia in Humans
...
1
2
3
4
5
...