Experimental Study of Intracisternal Administration of Tissue-Type Plasminogen Activator Followed by Cerebrospinal Fluid Drainage in the Ultra-Early Stage of Subarachnoid Haemorrhage

@article{Kawada1999ExperimentalSO,
  title={Experimental Study of Intracisternal Administration of Tissue-Type Plasminogen Activator Followed by Cerebrospinal Fluid Drainage in the Ultra-Early Stage of Subarachnoid Haemorrhage},
  author={Sanami Kawada and Kazushi Kinugasa and Toshinari Meguro and Nobuyuki Hirotsune and Koji Tokunaga and Ichiro Kamata and Hiroshi Nakashima and Takashi Ohmoto},
  journal={Acta Neurochirurgica},
  year={1999},
  volume={141},
  pages={1331-1338}
}
¶ This experimental study evaluated the effect of intrathecal injection of tissue-type plasminogen activator followed by cisternal drainage in the ultra-early stage of aneurysmal subarachnoid haemorrhage to prevent vasospasm.  Twenty Japanese white rabbits were divided into five groups. Either tPA (groups A, B, and E) or saline (groups C and D) was injected intrathecally 1 hour (groups A, B, C, and D) or 21 hours (group E) after the intrathecal injection of blood. Cerebrospinal fluid was… CONTINUE READING