Experimental Spinal Stenosis: Relationship Between Degree of Cauda Equina Compression, Neuropathology, and Pain

  title={Experimental Spinal Stenosis: Relationship Between Degree of Cauda Equina Compression, Neuropathology, and Pain},
  author={Miho Sekiguchi and Shin‐ichi Kikuchi and Robert R. Myers},
Study Design. An analysis of pathologic changes after different degrees of cauda equina compression. Objectives. To explore the association between the degree of the cauda equina compression and the extent of pathologic change, expression of tumor necrosis factor (TNF-&agr;), and neuropathic pain. To compare with distal nerve compression injury. Summary of Background Data. Compression of the cauda equina reduces blood flow in compressed nerve roots and causes TNF-&agr; expression and… 

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The findings suggest that local external compression causes ischemia in nerve fibers served by transperineurial vessels, with severe compression causing axonal damage, while lesser degrees of compressive injury are associated with demyelination.

Pathology of experimental nerve compression.

  • H. PowellR. Myers
  • Medicine, Biology
    Laboratory investigation; a journal of technical methods and pathology
  • 1986
The findings suggest that local external compression causes ischemia in nerve fibers served by transperineurial vessels, with severe compression causing axonal damage, while lesser degrees of compressive injury are associated with demyelination.

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